Mutations at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine
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چکیده
منابع مشابه
Mutations at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine.
Guanylate kinase (GMK) is an essential nucleoside monophosphate kinase that catalyzes the phosphorylation of guanine-monophosphate (GMP) and dGMP to yield GDP and dGDP, respectively, important precursors for nucleotide synthesis. GMK is also responsible for the activation of 6-thioguanine (6-TG), a drug widely used as chemotherapeutic agent to treat leukemia. Several mechanisms of resistance to...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2009
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzn078